8u1e: Difference between revisions
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New page: '''Unreleased structure''' The entry 8u1e is ON HOLD Authors: Sharma, S., Mehlman, S.T., Keedy, A.D. Description: High-resolution double vision of the archetypal protein tyrosine phosp... |
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==Apo protein tyrosine phosphatase 1B (PTP1B) at high resolution (1.43 A) in space group P43212 with two distinctly ordered chains== | |||
<StructureSection load='8u1e' size='340' side='right'caption='[[8u1e]], [[Resolution|resolution]] 1.43Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8u1e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8U1E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8U1E FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.43Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8u1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8u1e OCA], [https://pdbe.org/8u1e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8u1e RCSB], [https://www.ebi.ac.uk/pdbsum/8u1e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8u1e ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref> | |||
==See Also== | |||
*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: Keedy | __TOC__ | ||
[[Category: Mehlman | </StructureSection> | ||
[[Category: Sharma | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | |||
[[Category: Keedy AD]] | |||
[[Category: Mehlman ST]] | |||
[[Category: Sharma S]] | |||
