3jyu: Difference between revisions
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== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/UBP4_MOUSE UBP4_MOUSE] Deubiquitinating enzyme that removes conjugated ubiquitin from target proteins. Deubiquitinates PDPK1. Deubiquitinates TRIM21. Deubiquitinates receptor ADORA2A which increases the amount of functional receptor at the cell surface. Deubiquitinates HAS2. May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3. This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP. May also play a role in the regulation of quality control in the ER.[UniProtKB:Q13107] | [https://www.uniprot.org/uniprot/UBP4_MOUSE UBP4_MOUSE] Deubiquitinating enzyme that removes conjugated ubiquitin from target proteins (By similarity). Deubiquitinates PDPK1 (By similarity). Deubiquitinates TRIM21 (By similarity). Deubiquitinates receptor ADORA2A which increases the amount of functional receptor at the cell surface (By similarity). Deubiquitinates HAS2 (By similarity). Deubiquitinates RHEB in response to EGF signaling, promoting mTORC1 signaling (By similarity). May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3 (By similarity). This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP (By similarity). May also play a role in the regulation of quality control in the ER (By similarity).[UniProtKB:Q13107] | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jy/3jyu_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jy/3jyu_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
Latest revision as of 05:55, 17 October 2024
Crystal structure of the N-terminal domains of the ubiquitin specific peptidase 4 (USP4)
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