8k7b: Difference between revisions

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'''Unreleased structure'''


The entry 8k7b is ON HOLD  until Paper Publication
==post-occluded structure of human ABCB6 W546A mutant (ADP/VO4-bound)==
 
<StructureSection load='8k7b' size='340' side='right'caption='[[8k7b]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
Authors: Jin, M.S., Lee, S.S., Park, J.G., Jang, E., Choi, S.H., Kim, S., Kim, J.W.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8k7b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8K7B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8K7B FirstGlance]. <br>
Description: post-occluded structure of human ABCB6 W546A mutant (ADP/VO4-bound)
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.9&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AOV:ADP+ORTHOVANADATE'>AOV</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEV:(1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL+STEARATE'>PEV</scene></td></tr>
[[Category: Kim, S]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8k7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8k7b OCA], [https://pdbe.org/8k7b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8k7b RCSB], [https://www.ebi.ac.uk/pdbsum/8k7b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8k7b ProSAT]</span></td></tr>
[[Category: Lee, S.S]]
</table>
[[Category: Park, J.G]]
== Disease ==
[[Category: Kim, J.W]]
[https://www.uniprot.org/uniprot/ABCB6_HUMAN ABCB6_HUMAN] Ocular coloboma;Dyschromatosis universalis;Colobomatous microphthalmia. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  ABCB6 mutations are involved in familial pseudohyperkalemia, a dominantly inherited condition characterized by increased serum potassium levels, measured in whole-blood specimens stored at or below room temperature. This condition is not accompanied by clinical symptoms or biological signs except for borderline abnormalities of red cell shape (PubMed:23180570).<ref>PMID:23180570</ref>
[[Category: Choi, S.H]]
== Function ==
[[Category: Jin, M.S]]
[https://www.uniprot.org/uniprot/ABCB6_HUMAN ABCB6_HUMAN] Binds heme and porphyrins and functions in their ATP-dependent uptake into the mitochondria. Plays a crucial role in heme synthesis.<ref>PMID:10837493</ref> <ref>PMID:17006453</ref>
[[Category: Jang, E]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Choi SH]]
[[Category: Jang E]]
[[Category: Jin MS]]
[[Category: Kim JW]]
[[Category: Kim S]]
[[Category: Lee SS]]
[[Category: Park JG]]
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