8on9: Difference between revisions

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'''Unreleased structure'''


The entry 8on9 is ON HOLD
==ASSFVRIa-bound Malacoceros FaNaC1 in lipid nanodiscs==
<StructureSection load='8on9' size='340' side='right'caption='[[8on9]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8on9]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Malacoceros_fuliginosus Malacoceros fuliginosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ON9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ON9 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8on9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8on9 OCA], [https://pdbe.org/8on9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8on9 RCSB], [https://www.ebi.ac.uk/pdbsum/8on9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8on9 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Rapid signaling between neurons is mediated by ligand-gated ion channels, cell-surface proteins with an extracellular ligand-binding domain and a membrane-spanning ion channel domain. The degenerin/epithelial sodium channel (DEG/ENaC) superfamily is diverse in terms of its gating stimuli, with some DEG/ENaCs gated by neuropeptides, and others gated by pH, mechanical force or enzymatic activity. The mechanism by which ligands bind to and activate DEG/ENaCs is poorly understood. Here we dissected the structural basis for neuropeptide-gated activity of a neuropeptide-gated DEG/ENaC, FMRFamide-gated sodium channel 1 (FaNaC1) from the annelid worm Malacoceros fuliginosus, using cryo-electron microscopy. Structures of FaNaC1 in the ligand-free resting state and in several ligand-bound states reveal the ligand-binding site and capture the ligand-induced conformational changes of channel gating, which we verified with complementary mutagenesis experiments. Our results illuminate channel gating in DEG/ENaCs and offer a structural template for experimental dissection of channel pharmacology and ion conduction.


Authors:  
Structural basis for excitatory neuropeptide signaling.,Kalienkova V, Dandamudi M, Paulino C, Lynagh T Nat Struct Mol Biol. 2024 Apr;31(4):717-726. doi: 10.1038/s41594-023-01198-y. , Epub 2024 Feb 9. PMID:38337033<ref>PMID:38337033</ref>


Description:  
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
<div class="pdbe-citations 8on9" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Malacoceros fuliginosus]]
[[Category: Dandamudi M]]
[[Category: Kalienkova V]]
[[Category: Lynagh T]]
[[Category: Paulino C]]
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