8u1y: Difference between revisions
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==E.coli DsbA in complex with N-(4-(thiophen-3-yl)benzyl)cyclohexanamine== | |||
<StructureSection load='8u1y' size='340' side='right'caption='[[8u1y]], [[Resolution|resolution]] 1.74Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8u1y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8U1Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8U1Y FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8u1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8u1y OCA], [https://pdbe.org/8u1y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8u1y RCSB], [https://www.ebi.ac.uk/pdbsum/8u1y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8u1y ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Heras | == Function == | ||
[https://www.uniprot.org/uniprot/DSBA_ECOLI DSBA_ECOLI] Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. Required for pilus biogenesis. PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing (deletion of dsbA/dsbB, treatment with dithiothreitol). MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway.<ref>PMID:1429594</ref> <ref>PMID:22267510</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Escherichia coli K-12]] | |||
[[Category: Large Structures]] | |||
[[Category: Heras B]] | |||
[[Category: Wang G]] | |||
Latest revision as of 06:07, 11 September 2024
E.coli DsbA in complex with N-(4-(thiophen-3-yl)benzyl)cyclohexanamine
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