8u75: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 8u75 is ~~ON HOLD~~

==R399A mutant of sea urchin SLC9C1 at pH 6 in Na+ - Compressed state==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[8u75]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Strongylocentrotus_purpuratus Strongylocentrotus purpuratus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8U75 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=8U75 FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AJP:(25R)-2beta,15alpha-dihydroxy-5beta,8alpha,10alpha,14beta,17beta-spirostan-3alpha-yl+beta-D-glucopyranosyl-(1- 3)-beta-D-galactopyranosyl-(1- 2)-[beta-D-xylopyranosyl-(1- 3)]-beta-D-glucopyranosyl-(1- 4)-beta-D-galactopyranoside'>AJP</scene>, <scene name='pdbligand=POV:(2S)-3-(HEXADECANOYLOXY)-2-[(9Z)-OCTADEC-9-ENOYLOXY]PROPYL+2-(TRIMETHYLAMMONIO)ETHYL+PHOSPHATE'>POV</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=8u75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8u75 OCA], [https://pdbe.org/8u75 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8u75 RCSB], [https://www.ebi.ac.uk/pdbsum/8u75 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8u75 ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/SL9C1_STRPU SL9C1_STRPU] Electroneutral sodium:proton antiporter that regulates intracellular pH of sperm along with capacitation and fertility. Activated in response to egg-derived chemoattractants, couples membrane voltage to sodium:proton exchange and transduces membrane hyperpolarization to cytoplasmic alkalization to cAMP signaling and ultimately to sperm motility.<ref>PMID:30022052</ref> <ref>PMID:37880360</ref> <ref>PMID:37880361</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Strongylocentrotus purpuratus]]

[[Category: Chowdhury S]]

[[Category: Pal K]]

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-'''Unreleased structure'''
-The entry 8u75 is ON HOLD
+==R399A mutant of sea urchin SLC9C1 at pH 6 in Na+ - Compressed state==
+<StructureSection load='8u75' size='340' side='right'caption='[[8u75]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8u75]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Strongylocentrotus_purpuratus Strongylocentrotus purpuratus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8U75 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8U75 FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AJP:(25R)-2beta,15alpha-dihydroxy-5beta,8alpha,10alpha,14beta,17beta-spirostan-3alpha-yl+beta-D-glucopyranosyl-(1- 3)-beta-D-galactopyranosyl-(1- 2)-[beta-D-xylopyranosyl-(1- 3)]-beta-D-glucopyranosyl-(1- 4)-beta-D-galactopyranoside'>AJP</scene>, <scene name='pdbligand=POV:(2S)-3-(HEXADECANOYLOXY)-2-[(9Z)-OCTADEC-9-ENOYLOXY]PROPYL+2-(TRIMETHYLAMMONIO)ETHYL+PHOSPHATE'>POV</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8u75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8u75 OCA], [https://pdbe.org/8u75 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8u75 RCSB], [https://www.ebi.ac.uk/pdbsum/8u75 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8u75 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SL9C1_STRPU SL9C1_STRPU] Electroneutral sodium:proton antiporter that regulates intracellular pH of sperm along with capacitation and fertility. Activated in response to egg-derived chemoattractants, couples membrane voltage to sodium:proton exchange and transduces membrane hyperpolarization to cytoplasmic alkalization to cAMP signaling and ultimately to sperm motility.<ref>PMID:30022052</ref> <ref>PMID:37880360</ref> <ref>PMID:37880361</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Strongylocentrotus purpuratus]]
+[[Category: Chowdhury S]]
+[[Category: Pal K]]