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'''Unreleased structure'''


The entry 8w8r is ON HOLD
==Cryo-EM structure of the AA-14-bound GPR101-Gs complex==
 
<StructureSection load='8w8r' size='340' side='right'caption='[[8w8r]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
Authors: Sun, J.P., Yu, X., Gao, N., Yang, F., Wang, J.Y., Yang, Z., Guan, Y., Wang, G.P.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8w8r]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8W8R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8W8R FirstGlance]. <br>
Description: Cryo-EM structure of the AA-14-bound GPR101-Gs complex
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=U7D:1-(4-methylpyridin-2-yl)-3-[3-(trifluoromethyl)phenyl]thiourea'>U7D</scene></td></tr>
[[Category: Yu, X]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8w8r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8w8r OCA], [https://pdbe.org/8w8r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8w8r RCSB], [https://www.ebi.ac.uk/pdbsum/8w8r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8w8r ProSAT]</span></td></tr>
[[Category: Yang, Z]]
</table>
[[Category: Sun, J.P]]
== Function ==
[[Category: Wang, G.P]]
[https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref>
[[Category: Gao, N]]
== References ==
[[Category: Yang, F]]
<references/>
[[Category: Wang, J.Y]]
__TOC__
[[Category: Guan, Y]]
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Gao N]]
[[Category: Guan Y]]
[[Category: Sun JP]]
[[Category: Wang GP]]
[[Category: Wang JY]]
[[Category: Yang F]]
[[Category: Yang Z]]
[[Category: Yu X]]
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