8w9h: Difference between revisions
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New page: '''Unreleased structure''' The entry 8w9h is ON HOLD until Paper Publication Authors: Mori, S., Nagae, M., Yamasaki, S. Description: Crystal structure of anti-human CLEC12A antibody 50... |
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==Crystal structure of anti-human CLEC12A antibody 50C1== | |||
<StructureSection load='8w9h' size='340' side='right'caption='[[8w9h]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8w9h]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8W9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8W9H FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8w9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8w9h OCA], [https://pdbe.org/8w9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8w9h RCSB], [https://www.ebi.ac.uk/pdbsum/8w9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8w9h ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
C-type lectin receptors (CLRs) are a family of pattern recognition receptors, which detect a broad spectrum of ligands via small carbohydrate-recognition domains (CRDs). CLEC12A is an inhibitory CLR that recognizes crystalline structures such as monosodium urate crystals. CLEC12A also recognizes mycolic acid, a major component of mycobacterial cell walls, and suppresses host immune responses. Although CLEC12A could be a therapeutic target for mycobacterial infection, structural information on CLEC12A was not available. We report here the crystal structures of human CLEC12A (hCLEC12A) in ligand-free form and in complex with 50C1, its inhibitory antibody. 50C1 recognizes human-specific residues on the top face of hCLEC12A CRD. A comprehensive alanine scan demonstrated that the ligand-binding sites of mycolic acid and monosodium urate crystals may overlap with each other, suggesting that CLEC12A utilizes a common interface to recognize different types of ligands. Our results provide atomic insights into the blocking and ligand-recognition mechanisms of CLEC12A and leads to the design of CLR-specific inhibitors. | |||
Crystal structure of the complex of CLEC12A and an antibody that interferes with binding of diverse ligands.,Mori S, Nagae M, Yamasaki S Int Immunol. 2024 Apr 27;36(6):279-290. doi: 10.1093/intimm/dxae006. PMID:38386511<ref>PMID:38386511</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 8w9h" style="background-color:#fffaf0;"></div> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Mori S]] | |||
[[Category: Nagae M]] | |||
[[Category: Yamasaki S]] | |||
Latest revision as of 12:40, 23 October 2024
Crystal structure of anti-human CLEC12A antibody 50C1
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