8wgm: Difference between revisions
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==Quadruple mutant Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS V1/S, N51I+C59R+S108N+I164L) complexed with LA1, NADPH and dUMP== | |||
<StructureSection load='8wgm' size='340' side='right'caption='[[8wgm]], [[Resolution|resolution]] 2.15Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8wgm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_VS/1 Plasmodium falciparum VS/1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WGM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WGM FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wgm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wgm OCA], [https://pdbe.org/8wgm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wgm RCSB], [https://www.ebi.ac.uk/pdbsum/8wgm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wgm ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: Decharuangsilp | [https://www.uniprot.org/uniprot/A7UD81_PLAFA A7UD81_PLAFA] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism.[PIRNR:PIRNR000389] | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Plasmodium falciparum VS/1]] | ||
[[Category: Arwon U]] | |||
[[Category: Decharuangsilp S]] | |||
[[Category: Kamchonwongpaisan S]] | |||
[[Category: Saeyang T]] | |||
[[Category: Vanichtanankul J]] | |||
[[Category: Vitsupakorn D]] | |||
[[Category: Yuthavong Y]] | |||
Latest revision as of 06:09, 11 September 2024
Quadruple mutant Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS V1/S, N51I+C59R+S108N+I164L) complexed with LA1, NADPH and dUMP
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