8f5q: Difference between revisions

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8f5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8f5q OCA], [https://pdbe.org/8f5q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8f5q RCSB], [https://www.ebi.ac.uk/pdbsum/8f5q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8f5q ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8f5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8f5q OCA], [https://pdbe.org/8f5q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8f5q RCSB], [https://www.ebi.ac.uk/pdbsum/8f5q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8f5q ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PCNA_HUMAN PCNA_HUMAN] Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.<ref>PMID:19443450</ref> <ref>PMID:18719106</ref>
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==

Latest revision as of 09:36, 17 October 2024

Crystal structure of human PCNA in complex with the PIP box of FBH1

8f5q, resolution 1.90Å

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