8wkg: Difference between revisions

From Proteopedia
Jump to navigationJump to search
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
New page: '''Unreleased structure''' The entry 8wkg is ON HOLD Authors: Zhang, F.C., Huang, Y.Y. Description: Rational Design of Highly Selective PDE5 inhibitors for the Treatment of Idiopathic ...
 
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
 
(5 intermediate revisions by the same user not shown)
Line 1: Line 1:
'''Unreleased structure'''


The entry 8wkg is ON HOLD
==Rational Design of Highly Selective PDE5 inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis==
 
<StructureSection load='8wkg' size='340' side='right'caption='[[8wkg]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
Authors: Zhang, F.C., Huang, Y.Y.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8wkg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WKG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WKG FirstGlance]. <br>
Description: Rational Design of Highly Selective PDE5 inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=WDB:(~{E})-3-[2-[(3-chlorophenyl)methyl]-4-oxidanylidene-3~{H}-quinazolin-7-yl]prop-2-enoic+acid'>WDB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[Category: Zhang, F.C]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wkg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wkg OCA], [https://pdbe.org/8wkg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wkg RCSB], [https://www.ebi.ac.uk/pdbsum/8wkg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wkg ProSAT]</span></td></tr>
[[Category: Huang, Y.Y]]
</table>
== Function ==
[https://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Huang YY]]
[[Category: Zhang FC]]
Retrieved from "https://proteopedia.org/8wkg"