8u7s: Difference between revisions
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==SLC9C1 at pH 6 in presence of Na+== | |||
<StructureSection load='8u7s' size='340' side='right'caption='[[8u7s]], [[Resolution|resolution]] 4.18Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8u7s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Strongylocentrotus_purpuratus Strongylocentrotus purpuratus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8U7S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8U7S FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.18Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AJP:(25R)-2beta,15alpha-dihydroxy-5beta,8alpha,10alpha,14beta,17beta-spirostan-3alpha-yl+beta-D-glucopyranosyl-(1- 3)-beta-D-galactopyranosyl-(1- 2)-[beta-D-xylopyranosyl-(1- 3)]-beta-D-glucopyranosyl-(1- 4)-beta-D-galactopyranoside'>AJP</scene>, <scene name='pdbligand=POV:(2S)-3-(HEXADECANOYLOXY)-2-[(9Z)-OCTADEC-9-ENOYLOXY]PROPYL+2-(TRIMETHYLAMMONIO)ETHYL+PHOSPHATE'>POV</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8u7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8u7s OCA], [https://pdbe.org/8u7s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8u7s RCSB], [https://www.ebi.ac.uk/pdbsum/8u7s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8u7s ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SL9C1_STRPU SL9C1_STRPU] Electroneutral sodium:proton antiporter that regulates intracellular pH of sperm along with capacitation and fertility. Activated in response to egg-derived chemoattractants, couples membrane voltage to sodium:proton exchange and transduces membrane hyperpolarization to cytoplasmic alkalization to cAMP signaling and ultimately to sperm motility.<ref>PMID:30022052</ref> <ref>PMID:37880360</ref> <ref>PMID:37880361</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Strongylocentrotus purpuratus]] | |||
[[Category: Chowdhury S]] | |||
[[Category: Pal K]] | |||
Latest revision as of 21:35, 26 March 2025
SLC9C1 at pH 6 in presence of Na+
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