8snh

cytochrome bc1-cbb3 supercomplex from Pseudomonas aeruginosa

spinqualitylabelsall models 8snh, resolution 2.70Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8snh is a 13 chain structure with sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 2.7Å Ligands: CA, CU, FES, HEC, HEM, I7Y, U10 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q9HWP8_PSEAE Publication Abstract from PubMed Energy conversion by electron transport chains occurs through the sequential transfer of electrons between protein complexes and intermediate electron carriers, creating the proton motive force that enables ATP synthesis and membrane transport. These protein complexes can also form higher order assemblies known as respiratory supercomplexes (SCs). The electron transport chain of the opportunistic pathogen Pseudomonas aeruginosa is closely linked with its ability to invade host tissue, tolerate harsh conditions, and resist antibiotics but is poorly characterized. Here, we determine the structure of a P. aeruginosa SC that forms between the quinol:cytochrome c oxidoreductase (cytochrome bc(1)) and one of the organism's terminal oxidases, cytochrome cbb(3), which is found only in some bacteria. Remarkably, the SC structure also includes two intermediate electron carriers: a diheme cytochrome c(4) and a single heme cytochrome c(5). Together, these proteins allow electron transfer from ubiquinol in cytochrome bc(1) to oxygen in cytochrome cbb(3). We also present evidence that different isoforms of cytochrome cbb(3) can participate in formation of this SC without changing the overall SC architecture. Incorporating these different subunit isoforms into the SC would allow the bacterium to adapt to different environmental conditions. Bioinformatic analysis focusing on structural motifs in the SC suggests that cytochrome bc(1)-cbb(3) SCs also exist in other bacterial pathogens. Structure of the bc(1)-cbb(3) respiratory supercomplex from Pseudomonas aeruginosa.,Di Trani JM, Gheorghita AA, Turner M, Brzezinski P, Adelroth P, Vahidi S, Howell PL, Rubinstein JL Proc Natl Acad Sci U S A. 2023 Oct 3;120(40):e2307093120. doi: , 10.1073/pnas.2307093120. Epub 2023 Sep 26. PMID:37751552 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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