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[[Image:1ndn.jpg|left|200px]]


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==MOLECULAR STRUCTURE OF NICKED DNA. MODEL T4==
The line below this paragraph, containing "STRUCTURE_1ndn", creates the "Structure Box" on the page.
<StructureSection load='1ndn' size='340' side='right'caption='[[1ndn]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1ndn]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NDN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NDN FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ndn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ndn OCA], [https://pdbe.org/1ndn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ndn RCSB], [https://www.ebi.ac.uk/pdbsum/1ndn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ndn ProSAT]</span></td></tr>
{{STRUCTURE_1ndn|  PDB=1ndn  |  SCENE= }}
</table>
 
__TOC__
'''MOLECULAR STRUCTURE OF NICKED DNA. MODEL T4'''
</StructureSection>
 
[[Category: Large Structures]]
 
[[Category: Aymani J]]
==Overview==
[[Category: Coll M]]
The molecular structure of a nicked dodecamer DNA double helix, made of a ternary system containing d(CGCGAAAACGCG) + d(CGCGTT) + d(TTCGCG) oligonucleotides, has been determined by x-ray diffraction analysis at 3 A resolution. The molecule adopts a B-DNA conformation, not unlike those found in intact dodecamer DNA molecules crystallized in a somewhat different crystal lattice, despite a gap due to the absence of a phosphate group in the molecule. The helix has a distinct narrow minor groove near the center of the molecule at the AAAA region. This suggests that the internal stabilizing forces due to base stacking and hydrogen-bonding interactions are sufficient to overcome the loss of connectivity associated with the disruption of the covalent backbone of DNA.
[[Category: Rich A]]
 
[[Category: Van Boom JH]]
==About this Structure==
[[Category: Van Der Marel GA]]
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NDN OCA].  
[[Category: Wang AH-J]]
 
==Reference==
Molecular structure of nicked DNA: a substrate for DNA repair enzymes., Aymami J, Coll M, van der Marel GA, van Boom JH, Wang AH, Rich A, Proc Natl Acad Sci U S A. 1990 Apr;87(7):2526-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/2320572 2320572]
[[Category: Aymani, J.]]
[[Category: Boom, J H.Van.]]
[[Category: Coll, M.]]
[[Category: Marel, G A.Van Der.]]
[[Category: Rich, A.]]
[[Category: Wang, A H.J.]]
[[Category: B-dna]]
[[Category: Double helix]]
[[Category: Nicked]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 02:24:31 2008''

Latest revision as of 07:55, 14 February 2024

MOLECULAR STRUCTURE OF NICKED DNA. MODEL T4

1ndn, resolution 3.00Å

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