2il9: Difference between revisions

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2il9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2il9 OCA], [https://pdbe.org/2il9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2il9 RCSB], [https://www.ebi.ac.uk/pdbsum/2il9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2il9 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2il9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2il9 OCA], [https://pdbe.org/2il9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2il9 RCSB], [https://www.ebi.ac.uk/pdbsum/2il9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2il9 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Canonical cap-dependent translation initiation requires a large number of protein factors that act in a stepwise assembly process. In contrast, internal ribosomal entry sites (IRESs) are cis-acting RNAs that in some cases completely supplant these factors by recruiting and activating the ribosome using a single structured RNA. Here we present the crystal structures of the ribosome-binding domain from a Dicistroviridae intergenic region IRES at 3.1 angstrom resolution, providing a view of the prefolded architecture of an all-RNA translation initiation apparatus. Docking of the structure into cryo-electron microscopy reconstructions of an IRES-ribosome complex suggests a model for ribosome manipulation by a dynamic IRES RNA.
Structural basis for ribosome recruitment and manipulation by a viral IRES RNA.,Pfingsten JS, Costantino DA, Kieft JS Science. 2006 Dec 1;314(5804):1450-4. Epub 2006 Nov 23. PMID:17124290<ref>PMID:17124290</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2il9" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
</StructureSection>

Latest revision as of 09:03, 21 February 2024

Crystal Structure of Plautia Stali Intestine Virus Intergenic Region Internal Ribosome Entry Site Ribosomal Binding Domain RNA at 3.1 Angstroms

2il9, resolution 3.10Å

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