8sm3: Difference between revisions
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==Structure of Bacillus cereus VD045 Gabija GajA-GajB Complex== | |||
<StructureSection load='8sm3' size='340' side='right'caption='[[8sm3]], [[Resolution|resolution]] 3.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8sm3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_cereus_VD045 Bacillus cereus VD045]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SM3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SM3 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8sm3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8sm3 OCA], [https://pdbe.org/8sm3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8sm3 RCSB], [https://www.ebi.ac.uk/pdbsum/8sm3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8sm3 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GAJA_BACC6 GAJA_BACC6] Component of antiviral defense system Gabija type I, composed of GajA and GajB. Expression of Gabija type I in B.subtilis (strain BEST7003) confers resistance to phages phi105, phi29, rho14, SpBeta and SBSphiC (PubMed:29371424). An endonuclease that nicks double-stranded DNA within the sequence 5'-TNNNCGGGNNA-3' in the absence of nucleotides (NTP, dNTP and NDPs), cleaving after C-1. Has no detected ATPase activity. Expression of Gabija type I in E.coli B (strain ATCC 11303) confers resistance to phage T7 (PubMed:33885789). It is thought that this enzyme is strongly suppressed during physiological growth (in E.coli total nucleotide concentration is over 8.7 mM in mid-log phase), but during viral replication, when nucleotides are rapidly consumed, it is de-suppressed and degrades target DNA (Probable).<ref>PMID:29371424</ref> <ref>PMID:33885789</ref> <ref>PMID:33885789</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Bacillus cereus VD045]] | |||
[[Category: Large Structures]] | |||
[[Category: Antine SP]] | |||
[[Category: Johnson AG]] | |||
[[Category: Kranzusch PJ]] | |||
[[Category: Mooney SE]] | |||
Latest revision as of 07:32, 22 November 2023
Structure of Bacillus cereus VD045 Gabija GajA-GajB Complex
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