1w5z: Difference between revisions

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New page: left|200px<br /> <applet load="1w5z" size="450" color="white" frame="true" align="right" spinBox="true" caption="1w5z, resolution 1.86Å" /> '''AGAO COVALENT COMPL...
 
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[[Image:1w5z.gif|left|200px]]<br />
<applet load="1w5z" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1w5z, resolution 1.86&Aring;" />
'''AGAO COVALENT COMPLEX WITH BENZYLHYDRAZINE'''<br />


==About this Structure==
==AGAO covalent complex with Benzylhydrazine==
1W5Z is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Arthrobacter_globiformis Arthrobacter globiformis]] with CU, NA, SO4 and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.6 1.4.3.6]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W5Z OCA]].
<StructureSection load='1w5z' size='340' side='right'caption='[[1w5z]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1w5z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arthrobacter_globiformis Arthrobacter globiformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W5Z FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3TY:3-[(3E)-3-(BENZYLHYDRAZONO)-4-HYDROXY-6-OXOCYCLOHEXA-1,4-DIEN-1-YL]-L-ALANINE'>3TY</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w5z OCA], [https://pdbe.org/1w5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w5z RCSB], [https://www.ebi.ac.uk/pdbsum/1w5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w5z ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PAOX_ARTGO PAOX_ARTGO]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w5/1w5z_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1w5z ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Complexes of Arthrobacter globiformis amine oxidase (AGAO) with the inhibitors benzylhydrazine and tranylcypromine (an antidepressant drug) have been refined at 1.86 and 1.65 A resolution, respectively. Both inhibitors form covalent adducts with the TPQ cofactor. A tyrosine residue, proposed to act as a gate to the AGAO active site, is in its open conformation.
 
Complexes of the copper-containing amine oxidase from Arthrobacter globiformis with the inhibitors benzylhydrazine and tranylcypromine.,Langley DB, Trambaiolo DM, Duff AP, Dooley DM, Freeman HC, Guss JM Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jul 1;64(Pt, 7):577-83. Epub 2008 Jun 11. PMID:18607080<ref>PMID:18607080</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1w5z" style="background-color:#fffaf0;"></div>
 
==See Also==
*[[Copper amine oxidase 3D structures|Copper amine oxidase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arthrobacter globiformis]]
[[Category: Arthrobacter globiformis]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Dooley, D.M.]]
[[Category: Dooley DM]]
[[Category: Duff, A.P.]]
[[Category: Duff AP]]
[[Category: Freeman, H.C.]]
[[Category: Freeman HC]]
[[Category: Guss, J.M.]]
[[Category: Guss JM]]
[[Category: Juda, G.A.]]
[[Category: Juda GA]]
[[Category: Langley, D.B.]]
[[Category: Langley DB]]
[[Category: Shepard, E.M.]]
[[Category: Shepard EM]]
[[Category: Trambaiolo, D.M.]]
[[Category: Trambaiolo DM]]
[[Category: CU]]
[[Category: GOL]]
[[Category: NA]]
[[Category: SO4]]
[[Category: 3d-structure]]
[[Category: 3ty]]
[[Category: amine oxidase]]
[[Category: arthrobacter globiformis]]
[[Category: benzylhydrazine]]
[[Category: bh]]
[[Category: copper]]
[[Category: copper containing]]
[[Category: inhibited]]
[[Category: metal-binding]]
[[Category: oxidoreductase]]
[[Category: quinone]]
[[Category: tpq]]
 
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