8irj: Difference between revisions

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~~'''Unreleased structure'''~~

The entry ~~8irj is~~ ON ~~HOLD until Paper Publication~~

==Cryo-EM structure of an orphan GPCR==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[8irj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8IRJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8IRJ FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.49Å</td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8irj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8irj OCA], [https://pdbe.org/8irj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8irj RCSB], [https://www.ebi.ac.uk/pdbsum/8irj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8irj ProSAT]</span></td></tr>

</table>

== Disease ==

[https://www.uniprot.org/uniprot/GP179_HUMAN GP179_HUMAN] Congenital stationary night blindness. The disease is caused by variants affecting the gene represented in this entry.

== Function ==

[https://www.uniprot.org/uniprot/GP179_HUMAN GP179_HUMAN] Orphan receptor involved in vision (PubMed:22325362, PubMed:24084093). Required for signal transduction through retinal depolarizing bipolar cells (PubMed:22325362). Acts as an atypical G-protein coupled receptor that recruits and regulates the R7 group RGS-GNB5 complexes instead of activating G proteins: promotes the GTPase activator activity of R7 RGS proteins, increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (By similarity). Associates with components of metabotropic signaling cascade in retina ON-bipolar neurons, such as TRPM1 and GRM6: may control the ability of the GRM6 cascade to gate TRPM1 (By similarity).[UniProtKB:E9PY61]<ref>PMID:22325362</ref> <ref>PMID:24084093</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Jeong H]]

[[Category: Lee HH]]

[[Category: Yun Y]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8irj is ON HOLD  until Paper Publication
+==Cryo-EM structure of an orphan GPCR==
+<StructureSection load='8irj' size='340' side='right'caption='[[8irj]], [[Resolution|resolution]] 3.49&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8irj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8IRJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8IRJ FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.49&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8irj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8irj OCA], [https://pdbe.org/8irj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8irj RCSB], [https://www.ebi.ac.uk/pdbsum/8irj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8irj ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/GP179_HUMAN GP179_HUMAN] Congenital stationary night blindness. The disease is caused by variants affecting the gene represented in this entry.
+== Function ==
+[https://www.uniprot.org/uniprot/GP179_HUMAN GP179_HUMAN] Orphan receptor involved in vision (PubMed:22325362, PubMed:24084093). Required for signal transduction through retinal depolarizing bipolar cells (PubMed:22325362). Acts as an atypical G-protein coupled receptor that recruits and regulates the R7 group RGS-GNB5 complexes instead of activating G proteins: promotes the GTPase activator activity of R7 RGS proteins, increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (By similarity). Associates with components of metabotropic signaling cascade in retina ON-bipolar neurons, such as TRPM1 and GRM6: may control the ability of the GRM6 cascade to gate TRPM1 (By similarity).[UniProtKB:E9PY61]<ref>PMID:22325362</ref> <ref>PMID:24084093</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Jeong H]]
+[[Category: Lee HH]]
+[[Category: Yun Y]]