8wuz: Difference between revisions
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==Development of 2-imino-2,3,5,6,7,8-hexahydropyrido[4,3-d]pyrimidin-4(1H)-one derivatives as human caseinolytic peptidase P (hClpP) activators== | |||
<StructureSection load='8wuz' size='340' side='right'caption='[[8wuz]], [[Resolution|resolution]] 2.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8wuz]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WUZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WUZ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=XFU:5-[(3-fluorophenyl)methyl]-9-[[4-(trifluoromethyl)phenyl]methyl]-1,5,9,11-tetrazatricyclo[8.4.0.0^{2,7}]tetradeca-2(7),10-dien-8-one'>XFU</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wuz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wuz OCA], [https://pdbe.org/8wuz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wuz RCSB], [https://www.ebi.ac.uk/pdbsum/8wuz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wuz ProSAT]</span></td></tr> | ||
[[Category: Ding | </table> | ||
[[Category: Jiang | == Function == | ||
[[Category: Lu | [https://www.uniprot.org/uniprot/CLPP_HUMAN CLPP_HUMAN] Clp cleaves peptides in various proteins in a process that requires ATP hydrolysis. Clp may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates. | ||
[[Category: | __TOC__ | ||
[[Category: Xiao | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Chen M-R]] | |||
[[Category: Ding H]] | |||
[[Category: Jiang J-X]] | |||
[[Category: Lu M-L]] | |||
[[Category: Sun H-Y]] | |||
[[Category: Xiao Y-B]] | |||
Latest revision as of 07:11, 23 October 2024
Development of 2-imino-2,3,5,6,7,8-hexahydropyrido[4,3-d]pyrimidin-4(1H)-one derivatives as human caseinolytic peptidase P (hClpP) activators
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