1nxb: Difference between revisions

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[[Image:1nxb.gif|left|200px]]


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==STRUCTURE AND FUNCTION OF SNAKE VENOM CURARIMIMETIC NEUROTOXINS==
The line below this paragraph, containing "STRUCTURE_1nxb", creates the "Structure Box" on the page.
<StructureSection load='1nxb' size='340' side='right'caption='[[1nxb]], [[Resolution|resolution]] 1.38&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1nxb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Laticauda_semifasciata Laticauda semifasciata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NXB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NXB FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.38&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_1nxb|  PDB=1nxb  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nxb OCA], [https://pdbe.org/1nxb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nxb RCSB], [https://www.ebi.ac.uk/pdbsum/1nxb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nxb ProSAT]</span></td></tr>
 
</table>
'''STRUCTURE AND FUNCTION OF SNAKE VENOM CURARIMIMETIC NEUROTOXINS'''
== Function ==
 
[https://www.uniprot.org/uniprot/3S1EB_LATSE 3S1EB_LATSE] Binds with high affinity to muscular nicotinic acetylcholine receptors (nAChRs) (tested on Torpedo marmorata, Kd=0.07 nM), and with low affinity to neuronal alpha-7/CHRNA7 nAChRs (tested on chimeric alpha-7/CHRNA7, Kd=22 uM) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission (PubMed:7721859). Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site.<ref>PMID:9305882</ref>
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
1NXB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Laticauda_semifasciata Laticauda semifasciata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NXB OCA].  
Check<jmol>
 
  <jmolCheckbox>
==Reference==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nx/1nxb_consurf.spt"</scriptWhenChecked>
Structure and function of snake venom curarimimetic neurotoxins., Tsernoglou D, Petsko GA, Hudson RA, Mol Pharmacol. 1978 Jul;14(4):710-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/683181 683181]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nxb ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Laticauda semifasciata]]
[[Category: Laticauda semifasciata]]
[[Category: Single protein]]
[[Category: Petsko GA]]
[[Category: Petsko, G A.]]
[[Category: Tsernoglou D]]
[[Category: Tsernoglou, D.]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 03:05:26 2008''
Retrieved from "https://proteopedia.org/1nxb"