2jii: Difference between revisions
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New page: left|200px<br /> <applet load="2jii" size="450" color="white" frame="true" align="right" spinBox="true" caption="2jii, resolution 2.00Å" /> '''STRUCTURE OF VACCIN... |
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== | ==Structure of vaccinia related kinase 3== | ||
<StructureSection load='2jii' size='340' side='right'caption='[[2jii]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2jii]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JII OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JII FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jii OCA], [https://pdbe.org/2jii PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jii RCSB], [https://www.ebi.ac.uk/pdbsum/2jii PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jii ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/VRK3_HUMAN VRK3_HUMAN] Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus.<ref>PMID:14645249</ref> <ref>PMID:19141289</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ji/2jii_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jii ConSurf]. | |||
<div style="clear:both"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith CH]] | ||
[[Category: Bunkoczi | [[Category: Bunkoczi G]] | ||
[[Category: Burgess-Brown | [[Category: Burgess-Brown N]] | ||
[[Category: Cooper | [[Category: Cooper C]] | ||
[[Category: Edwards A]] | |||
[[Category: Edwards | [[Category: Eswaran J]] | ||
[[Category: Eswaran | [[Category: Fedorov O]] | ||
[[Category: Fedorov | [[Category: Keates T]] | ||
[[Category: Keates | [[Category: Knapp S]] | ||
[[Category: Knapp | [[Category: Pike ACW]] | ||
[[Category: Pike | [[Category: Salah E]] | ||
[[Category: Salah | [[Category: Savitsky P]] | ||
[[Category: Savitsky | [[Category: Sobott F]] | ||
[[Category: Sobott | [[Category: Sundstrom M]] | ||
[[Category: Sundstrom | [[Category: Ugochukwu E]] | ||
[[Category: Ugochukwu | [[Category: Uppenberg J]] | ||
[[Category: Uppenberg | [[Category: Weigelt J]] | ||
[[Category: Weigelt | [[Category: Von Delft F]] | ||
[[Category: | |||
