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New page: '''Unreleased structure''' The entry 8wy7 is ON HOLD Authors: Xu, H., Zhao, X., Shen, H., Xu, Y., Wu, X. Description: Crystal Structure of the first bromodomain of human BRD4 in comple...
 
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'''Unreleased structure'''


The entry 8wy7 is ON HOLD
==Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor 22==
 
<StructureSection load='8wy7' size='340' side='right'caption='[[8wy7]], [[Resolution|resolution]] 2.83&Aring;' scene=''>
Authors: Xu, H., Zhao, X., Shen, H., Xu, Y., Wu, X.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8wy7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WY7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WY7 FirstGlance]. <br>
Description: Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor 22
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.83&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XHN:2-[[5-[2-(4-fluoranyl-2,6-dimethyl-phenoxy)-5-(2-oxidanylpropan-2-yl)phenyl]-1-methyl-2-oxidanylidene-pyridin-4-yl]amino]-~{N}-(4-oxidanylcyclohexyl)ethanamide'>XHN</scene></td></tr>
[[Category: Wu, X]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wy7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wy7 OCA], [https://pdbe.org/8wy7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wy7 RCSB], [https://www.ebi.ac.uk/pdbsum/8wy7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wy7 ProSAT]</span></td></tr>
[[Category: Zhao, X]]
</table>
[[Category: Xu, H]]
== Disease ==
[[Category: Shen, H]]
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
[[Category: Xu, Y]]
== Function ==
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Shen H]]
[[Category: Wu X]]
[[Category: Xu H]]
[[Category: Xu Y]]
[[Category: Zhao X]]
Retrieved from "https://proteopedia.org/8wy7"