8wsa: Difference between revisions

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'''Unreleased structure'''


The entry 8wsa is ON HOLD  until Paper Publication
==Cryo-EM Structure of Mouse TLR4/MD-2/DLAM5 Complex==
 
<StructureSection load='8wsa' size='340' side='right'caption='[[8wsa]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8wsa]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WSA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WSA FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0IL:(3R)-3-tetradecanoyloxytetradecanoic+acid'>0IL</scene>, <scene name='pdbligand=2IL:(3R)-3-(dodecanoyloxy)tetradecanoic+acid'>2IL</scene>, <scene name='pdbligand=A1L01:(3~{S})-3-decanoyloxytetradecanoic+acid'>A1L01</scene>, <scene name='pdbligand=GP4:GLUCOSAMINE+4-PHOSPHATE'>GP4</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=X6N:[(2~{R},3~{S},4~{R},5~{S})-2-(hydroxymethyl)-5-methoxy-4,6-bis(oxidanyl)oxan-3-yl]+dihydrogen+phosphate'>X6N</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wsa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wsa OCA], [https://pdbe.org/8wsa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wsa RCSB], [https://www.ebi.ac.uk/pdbsum/8wsa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wsa ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LY96_MOUSE LY96_MOUSE] Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both MD2 and TLR4, but not TLR4 alone, respond to LPS (By similarity).
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Fu Y]]
[[Category: Kim H]]
[[Category: Kim HM]]
Retrieved from "https://proteopedia.org/8wsa"