8x73: Difference between revisions
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New page: '''Unreleased structure''' The entry 8x73 is ON HOLD Authors: Zhang, H., Luo, C. Description: Crystal structure of Peroxiredoxin I in complex with compound 19-069 [[Category: Unrelease... |
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==Crystal structure of Peroxiredoxin I in complex with compound 19-069== | |||
<StructureSection load='8x73' size='340' side='right'caption='[[8x73]], [[Resolution|resolution]] 1.61Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8x73]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8X73 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8X73 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.61Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YC0:methyl+(2~{S})-2-[[(2~{R},4~{a}~{S},6~{a}~{R},6~{a}~{S},14~{a}~{S},14~{b}~{R})-2,4~{a},6~{a},6~{a},9,14~{a}-hexamethyl-10-oxidanyl-11-oxidanylidene-1,3,4,5,6,13,14,14~{b}-octahydropicen-2-yl]carbamoylamino]-3-oxidanyl-propanoate'>YC0</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8x73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8x73 OCA], [https://pdbe.org/8x73 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8x73 RCSB], [https://www.ebi.ac.uk/pdbsum/8x73 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8x73 ProSAT]</span></td></tr> | ||
[[Category: Luo | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/PRDX1_HUMAN PRDX1_HUMAN] Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Luo C]] | |||
[[Category: Zhang H]] | |||
Latest revision as of 05:56, 19 June 2024
Crystal structure of Peroxiredoxin I in complex with compound 19-069
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