Acetazolamide: Difference between revisions
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<StructureSection load='' size='340' side='right' caption=' | <StructureSection load='' size='340' side='right' caption='Acetazolamide' scene='10/1011417/Cv/1'> | ||
Acetazolamide, sold under the trade name Diamox among others, is a medication used to treat glaucoma, epilepsy, acute mountain sickness, periodic paralysis, idiopathic intracranial hypertension (raised brain pressure of unclear cause), heart failure and to alkalinize urine.<ref name="a2">[https://www.drugs.com/monograph/acetazolamide.html "Acetazolamide".] The American Society of Health-System Pharmacists. Archived from the original on 28 December 2016. Retrieved 8 December 2016.</ref><ref name="a3">PMID:28758206</ref> See also [https://en.wikipedia.org/wiki/Acetazolamide Acetazolamide]. | Acetazolamide, sold under the trade name Diamox among others, is a medication used to treat glaucoma, epilepsy, acute mountain sickness, periodic paralysis, idiopathic intracranial hypertension (raised brain pressure of unclear cause), heart failure and to alkalinize urine.<ref name="a2">[https://www.drugs.com/monograph/acetazolamide.html "Acetazolamide".] The American Society of Health-System Pharmacists. Archived from the original on 28 December 2016. Retrieved 8 December 2016.</ref><ref name="a3">PMID:28758206</ref> See also [https://en.wikipedia.org/wiki/Acetazolamide Acetazolamide]. | ||
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Thus, by disrupting this process with acetazolamide, urinary Na+ and bicarbonate (HCO3−) are increased, and urinary H+ and Cl− are decreased. Inversely, serum Na+ and bicarbonate (HCO3−) are decreased, and serum H+ and Cl− are increased. H2O generally follows sodium, and so this is how the clinical diuretic effect is achieved, which reduces blood volume and thus preload on the heart to improve contractility and reduce blood pressure, or achieve other desired clinical effects of reduced blood volume such as reducing edema or intracranial pressure.<ref name="a28">PMID:19948674</ref> | Thus, by disrupting this process with acetazolamide, urinary Na+ and bicarbonate (HCO3−) are increased, and urinary H+ and Cl− are decreased. Inversely, serum Na+ and bicarbonate (HCO3−) are decreased, and serum H+ and Cl− are increased. H2O generally follows sodium, and so this is how the clinical diuretic effect is achieved, which reduces blood volume and thus preload on the heart to improve contractility and reduce blood pressure, or achieve other desired clinical effects of reduced blood volume such as reducing edema or intracranial pressure.<ref name="a28">PMID:19948674</ref> | ||
<scene name='10/1011417/Cv/2'>CARBONIC ANHYDRASE II COMPLEXED WITH ACETAZOLAMIDE</scene> ([[2h4n]]). | <scene name='10/1011417/Cv/2'>CARBONIC ANHYDRASE II COMPLEXED WITH ACETAZOLAMIDE</scene> ([[2h4n]]). | ||
<scene name='10/1011417/Binding_site/1'>Acetazolamide binding site</scene>. | |||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
