8wyg: Difference between revisions

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'''Unreleased structure'''


The entry 8wyg is ON HOLD  until Paper Publication
==Crystal Structure of the second bromodomain of human BRD2 in complex with the inhibitor 22==
 
<StructureSection load='8wyg' size='340' side='right'caption='[[8wyg]], [[Resolution|resolution]] 3.13&Aring;' scene=''>
Authors: Xu, H., Zhao, X., Shen, H., Xu, Y., Wu, X.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8wyg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WYG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WYG FirstGlance]. <br>
Description: Crystal Structure of the second bromodomain of human BRD2 in complex with the inhibitor 22
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.13&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XHN:2-[[5-[2-(4-fluoranyl-2,6-dimethyl-phenoxy)-5-(2-oxidanylpropan-2-yl)phenyl]-1-methyl-2-oxidanylidene-pyridin-4-yl]amino]-~{N}-(4-oxidanylcyclohexyl)ethanamide'>XHN</scene></td></tr>
[[Category: Wu, X]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wyg OCA], [https://pdbe.org/8wyg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wyg RCSB], [https://www.ebi.ac.uk/pdbsum/8wyg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wyg ProSAT]</span></td></tr>
[[Category: Zhao, X]]
</table>
[[Category: Xu, H]]
== Function ==
[[Category: Shen, H]]
[https://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>
[[Category: Xu, Y]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Shen H]]
[[Category: Wu X]]
[[Category: Xu H]]
[[Category: Xu Y]]
[[Category: Zhao X]]
Retrieved from "https://proteopedia.org/8wyg"