8vc2: Difference between revisions
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==CryoEM structure of insect gustatory receptor BmGr9 in the presence of fructose== | |||
<StructureSection load='8vc2' size='340' side='right'caption='[[8vc2]], [[Resolution|resolution]] 3.98Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8vc2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bombyx_mori Bombyx mori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8VC2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8VC2 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.98Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PSC:(7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM+4-OXIDE'>PSC</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8vc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8vc2 OCA], [https://pdbe.org/8vc2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8vc2 RCSB], [https://www.ebi.ac.uk/pdbsum/8vc2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8vc2 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/B3GTD7_BOMMO B3GTD7_BOMMO] Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.[RuleBase:RU363108] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Gustatory receptors (GRs) are critical for insect chemosensation and are potential targets for controlling pests and disease vectors, making their structural investigation a vital step toward such applications. We present structures of Bombyx mori Gr9 (BmGr9), a fructose-gated cation channel, in agonist-free and fructose-bound states. BmGr9 forms a tetramer similar to distantly related insect odorant receptors (ORs). Upon fructose binding, BmGr9's channel gate opens through helix S7b movements. In contrast to ORs, BmGr9's ligand-binding pocket, shaped by a kinked helix S4 and a shorter extracellular S3-S4 loop, is larger and solvent accessible in both agonist-free and fructose-bound states. Also, unlike ORs, fructose binding by BmGr9 involves helix S5 and a pocket lined with aromatic and polar residues. Structure-based sequence alignments reveal distinct patterns of ligand-binding pocket residue conservation in GR subfamilies associated with different ligand classes. These data provide insight into the molecular basis of GR ligand specificity and function. | |||
Structural basis of ligand specificity and channel activation in an insect gustatory receptor.,Frank HM, Walujkar S, Walsh RM Jr, Laursen WJ, Theobald DL, Garrity PA, Gaudet R Cell Rep. 2024 Apr 23;43(4):114035. doi: 10.1016/j.celrep.2024.114035. Epub 2024 , Apr 3. PMID:38573859<ref>PMID:38573859</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 8vc2" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Bombyx mori]] | |||
[[Category: Large Structures]] | |||
[[Category: Frank HM]] | |||
[[Category: Garrity PA]] | |||
[[Category: Gaudet R]] | |||
[[Category: Walsh Jr RM]] | |||
