8xgm: Difference between revisions
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New page: '''Unreleased structure''' The entry 8xgm is ON HOLD Authors: Liu, A.J., Liu, Y.Z., Ye, R.D. Description: Cryo-EM structure of human GPR1 bound to chemerin [[Category: Unreleased Struc... |
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==Cryo-EM structure of human GPR1 bound to chemerin== | |||
<StructureSection load='8xgm' size='340' side='right'caption='[[8xgm]], [[Resolution|resolution]] 3.29Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8xgm]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Vicugna_pacos Vicugna pacos]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8XGM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8XGM FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.29Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8xgm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8xgm OCA], [https://pdbe.org/8xgm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8xgm RCSB], [https://www.ebi.ac.uk/pdbsum/8xgm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8xgm ProSAT]</span></td></tr> | ||
[[Category: Liu | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/CML2_HUMAN CML2_HUMAN] Receptor for chemoattractant adipokine chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation and energy homesotasis (PubMed:18165312, PubMed:27716822). Signals mainly via beta-arrestin pathway. Binding of RARRES2 activates weakly G proteins, calcium mobilization and MAPK1/MAPK3 (ERK1/2) phosphorylation too (PubMed:27716822). Acts also as a receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity).[UniProtKB:Q8K087]<ref>PMID:18165312</ref> <ref>PMID:27716822</ref> (Microbial infection) Coreceptor for HIV-1.<ref>PMID:10233994</ref> | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Vicugna pacos]] | |||
[[Category: Liu AJ]] | |||
[[Category: Liu YZ]] | |||
[[Category: Ye RD]] | |||
Latest revision as of 13:08, 21 August 2024
Cryo-EM structure of human GPR1 bound to chemerin
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