Thiolase

spinqualitylabelsall models Human 3-ketoacyl-CoA complex with CoA and ethylene glycol (PDB code 4c2j) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Two different classes of thiolases are found. Degrative thiolase like 3-ketoacyl-CoA thiolase (KCT) is involved in fatty acid beta oxidation. Biosynthetic thiolases like acetoacetyl-CoA thiolase (ACT) or acetyl-CoA acetyltransferase are involved in the thiolysis of acetoacetyl-CoA. For bacterial thiolase see Bacterial thiolase SCP2-thiolase converts in the bile acid synthesis pathway 24-keto-THC-CoA into choloyl-CoA and propionyl-CoA. For zebrafish thiolase see SCP2-thiolase. SCP is Sterol Carrier Protein. U34-tRNA-thiolase thiolates uridine 34 in tRNA anticodon loop which guarantees the fidelity of protein translation in archaea. See also Mevalonate pathway Structural highlights The active site of 3-ketoacyl-CoA thiolase contains CoA. Water molecules are shown as red spheres. 3D Structures of Thiolase Thiolase 3D structures

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