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New page: left|200px<br /> <applet load="1quu" size="450" color="white" frame="true" align="right" spinBox="true" caption="1quu, resolution 2.5Å" /> '''CRYSTAL STRUCTURE OF...
 
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[[Image:1quu.gif|left|200px]]<br />
<applet load="1quu" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1quu, resolution 2.5&Aring;" />
'''CRYSTAL STRUCTURE OF TWO CENTRAL SPECTRIN-LIKE REPEATS FROM ALPHA-ACTININ'''<br />


==Overview==
==CRYSTAL STRUCTURE OF TWO CENTRAL SPECTRIN-LIKE REPEATS FROM ALPHA-ACTININ==
We have determined the crystal structure of the two central repeats in the, alpha-actinin rod at 2.5 A resolution. The repeats are connected by a, helical linker and form a symmetric, antiparallel dimer in which the, repeats are aligned rather than staggered. Using this structure, which, reveals the structural principle that governs the architecture of, alpha-actinin, we have devised a plausible model of the entire, alpha-actinin rod. The electrostatic properties explain how the two, alpha-actinin subunits assemble in an antiparallel fashion, placing the, actin-binding sites at both ends of the rod. This molecular architecture, results in a protein that is able to form cross-links between actin, filaments.
<StructureSection load='1quu' size='340' side='right'caption='[[1quu]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1quu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QUU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QUU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1quu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1quu OCA], [https://pdbe.org/1quu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1quu RCSB], [https://www.ebi.ac.uk/pdbsum/1quu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1quu ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/ACTN2_HUMAN ACTN2_HUMAN] Defects in ACTN2 are the cause of cardiomyopathy dilated type 1AA (CMD1AA) [MIM:[https://omim.org/entry/612158 612158]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.<ref>PMID:14567970</ref>
== Function ==
[https://www.uniprot.org/uniprot/ACTN2_HUMAN ACTN2_HUMAN] F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qu/1quu_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1quu ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
1QUU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1QUU OCA].
*[[Actinin 3D structures|Actinin 3D structures]]
 
== References ==
==Reference==
<references/>
Structure of the alpha-actinin rod: molecular basis for cross-linking of actin filaments., Djinovic-Carugo K, Young P, Gautel M, Saraste M, Cell. 1999 Aug 20;98(4):537-46. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10481917 10481917]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Djinovic-Carugo, K.]]
[[Category: Djinovic-Carugo K]]
[[Category: Gautel, M.]]
[[Category: Gautel M]]
[[Category: Saraste, M.]]
[[Category: Saraste M]]
[[Category: Young, P.]]
[[Category: Young P]]
[[Category: triple-helix coiled coil]]
[[Category: Z-disk]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 18:56:52 2007''

Latest revision as of 08:18, 14 February 2024

CRYSTAL STRUCTURE OF TWO CENTRAL SPECTRIN-LIKE REPEATS FROM ALPHA-ACTININ

1quu, resolution 2.50Å

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