8ffm: Difference between revisions
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==Wildtype rat TRPV2 in nanodiscs bound to RR and 2-APB== | |||
<StructureSection load='8ffm' size='340' side='right'caption='[[8ffm]], [[Resolution|resolution]] 2.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8ffm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FFM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FFM FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FZ4:2-aminoethyl+diphenylborinate'>FZ4</scene>, <scene name='pdbligand=PEX:1,2-DIDECANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>PEX</scene>, <scene name='pdbligand=R2R:ruthenium(6+)+azanide+pentaamino(oxido)ruthenium+(1/4/2)'>R2R</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ffm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ffm OCA], [https://pdbe.org/8ffm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ffm RCSB], [https://www.ebi.ac.uk/pdbsum/8ffm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ffm ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TRPV2_RAT TRPV2_RAT] Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by growth factors, like IGF1, PDGF and morphogenetic neuropeptide/head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH (By similarity).<ref>PMID:10201375</ref> <ref>PMID:15249591</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Rattus norvegicus]] | |||
[[Category: De Jesus-Perez JJ]] | |||
[[Category: Fluck EC]] | |||
[[Category: Moiseenkova-Bell VY]] | |||
[[Category: Protopopova AD]] | |||
[[Category: Pumroy RA]] | |||
[[Category: Rocereta JA]] | |||
Latest revision as of 15:14, 13 August 2026
Wildtype rat TRPV2 in nanodiscs bound to RR and 2-APB
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