8h94: Difference between revisions

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'''Unreleased structure'''


The entry 8h94 is ON HOLD  until 2025-04-24
==Structure of mouse SCMC bound with KH domain of FILIA==
 
<StructureSection load='8h94' size='340' side='right'caption='[[8h94]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8h94]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8H94 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8H94 FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8h94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8h94 OCA], [https://pdbe.org/8h94 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8h94 RCSB], [https://www.ebi.ac.uk/pdbsum/8h94 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8h94 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TLE6_MOUSE TLE6_MOUSE] Component of the subcortical maternal complex (SCMC), a multiprotein complex that plays a key role in early embryonic development (PubMed:18804437, PubMed:25208553, PubMed:31575650, PubMed:37922900). The SCMC complex is a structural constituent of cytoplasmic lattices, which consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos (PubMed:31575650, PubMed:37922900). They are required to store maternal proteins critical for embryonic development, such as proteins that control epigenetic reprogramming of the preimplantation embryo, and prevent their degradation or activation (PubMed:37922900). Also required for spermatogenesis: regulates spermatogonia proliferation and cell cycle progression, potentially via regulation of cell cycle regulatory genes such as; CEBPB, CEBPA, CSF3, PCNA, and CDK4 (PubMed:32823735, PubMed:39512902). Suppresses FOXG1/BF-1-mediated transcriptional repression by inhibiting interaction of the transcriptional corepressor TLE1 with FOXG1 which promotes cortical neuron differentiation (PubMed:16314515). Acts as a transcriptional corepressor of NFATC1-mediated gene expression by contributing to PAX6-mediated repression (PubMed:23990468).<ref>PMID:16314515</ref> <ref>PMID:18804437</ref> <ref>PMID:23990468</ref> <ref>PMID:25208553</ref> <ref>PMID:31575650</ref> <ref>PMID:32823735</ref> <ref>PMID:37922900</ref> <ref>PMID:39512902</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Chi P]]
[[Category: Deng D]]
[[Category: Han Z]]
[[Category: Li J]]
[[Category: Ou G]]
Retrieved from "https://proteopedia.org/8h94"