7gth: Difference between revisions
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New page: '''Unreleased structure''' The entry 7gth is ON HOLD Authors: Mehlman, T., Ginn, H.M., Keedy, D.A. Description: PanDDA Analysis group deposition --Crystal structure of PTP1B in complex... |
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==PanDDA Analysis group deposition -- Crystal structure of PTP1B in complex with FMOOA000637a== | |||
<StructureSection load='7gth' size='340' side='right'caption='[[7gth]], [[Resolution|resolution]] 1.66Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7gth]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7GTH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7GTH FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.66Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1ABM:(1~{S},10~{R})-4-methyl-8-oxa-12,16-diazatetracyclo[8.6.0.0^{2,7}.0^{12,16}]hexadeca-2,4,6-trien-13-one'>A1ABM</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7gth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7gth OCA], [https://pdbe.org/7gth PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7gth RCSB], [https://www.ebi.ac.uk/pdbsum/7gth PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7gth ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref> | |||
==See Also== | |||
*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | |||
[[Category: Ginn HM]] | |||
[[Category: Keedy DA]] | |||
[[Category: Mehlman T]] | |||
Latest revision as of 08:40, 11 December 2025
PanDDA Analysis group deposition -- Crystal structure of PTP1B in complex with FMOOA000637a
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