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'''Unreleased structure'''


The entry 8ihu is ON HOLD  until 2025-05-23
==Cryo-EM structure of an amyloid fibril formed by ALS-causing SOD1 mutation G85R==
 
<StructureSection load='8ihu' size='340' side='right'caption='[[8ihu]], [[Resolution|resolution]] 2.97&Aring;' scene=''>
Authors: Wang, L.Q., Ma, Y.Y., Zhang, M.Y., Yuan, H.Y., Li, X.N., Zhao, K., Chen, J., Li, D., Wang, Z.Z., Le, W.D., Liu, C., Liang, Y.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8ihu]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8IHU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8IHU FirstGlance]. <br>
Description: Cryo-EM structure of an amyloid fibril formed by ALS-causing SOD1 mutation G85R
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.97&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ihu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ihu OCA], [https://pdbe.org/8ihu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ihu RCSB], [https://www.ebi.ac.uk/pdbsum/8ihu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ihu ProSAT]</span></td></tr>
[[Category: Wang, Z.Z]]
</table>
[[Category: Li, D]]
== Disease ==
[[Category: Li, X.N]]
[https://www.uniprot.org/uniprot/SODC_HUMAN SODC_HUMAN] Defects in SOD1 are the cause of amyotrophic lateral sclerosis type 1 (ALS1) [MIM:[https://omim.org/entry/105400 105400]. ALS1 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of cases leading to familial forms.<ref>PMID:12963370</ref> <ref>PMID:19741096</ref> <ref>PMID:8528216</ref> <ref>PMID:8682505</ref> <ref>PMID:9541385</ref> <ref>PMID:12754496</ref> <ref>PMID:15056757</ref> <ref>PMID:18378676</ref> [:]<ref>PMID:8446170</ref> <ref>PMID:8351519</ref> <ref>PMID:8179602</ref> <ref>PMID:7980516</ref> <ref>PMID:8069312</ref> <ref>PMID:7951252</ref> <ref>PMID:7881433</ref> <ref>PMID:7836951</ref> <ref>PMID:7997024</ref> <ref>PMID:7870076</ref> <ref>PMID:7887412</ref> <ref>PMID:7795609</ref> <ref>PMID:7655468</ref> <ref>PMID:7655469</ref> <ref>PMID:7655471</ref> <ref>PMID:7700376</ref> <ref>PMID:7647793</ref> <ref>PMID:7501156</ref> <ref>PMID:7496169</ref> <ref>PMID:8938700</ref> <ref>PMID:8907321</ref> <ref>PMID:8990014</ref> <ref>PMID:9101297</ref> <ref>PMID:9455977</ref> <ref>PMID:10732812</ref> <ref>PMID:9131652</ref> <ref>PMID:10400992</ref> <ref>PMID:10430435</ref> <ref>PMID:11535232</ref> <ref>PMID:11369193</ref> <ref>PMID:12402272</ref> <ref>PMID:12145308</ref> <ref>PMID:14506936</ref> <ref>PMID:18552350</ref> <ref>PMID:18301754</ref> <ref>PMID:21247266</ref> <ref>PMID:21220647</ref>
[[Category: Liu, C]]
== Function ==
[[Category: Chen, J]]
[https://www.uniprot.org/uniprot/SODC_HUMAN SODC_HUMAN] Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
[[Category: Yuan, H.Y]]
== References ==
[[Category: Ma, Y.Y]]
<references/>
[[Category: Liang, Y]]
__TOC__
[[Category: Le, W.D]]
</StructureSection>
[[Category: Zhang, M.Y]]
[[Category: Homo sapiens]]
[[Category: Wang, L.Q]]
[[Category: Large Structures]]
[[Category: Zhao, K]]
[[Category: Chen J]]
[[Category: Le WD]]
[[Category: Li D]]
[[Category: Li XN]]
[[Category: Liang Y]]
[[Category: Liu C]]
[[Category: Ma YY]]
[[Category: Wang LQ]]
[[Category: Wang ZZ]]
[[Category: Yuan HY]]
[[Category: Zhang MY]]
[[Category: Zhao K]]
Retrieved from "https://proteopedia.org/8ihu"