8w7e: Difference between revisions
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==Design, synthesis and biological evaluations of novel small molecular hyper-activators of human caseinolytic peptidase P (hClpP)== | |||
<StructureSection load='8w7e' size='340' side='right'caption='[[8w7e]], [[Resolution|resolution]] 2.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8w7e]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8W7E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8W7E FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8w7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8w7e OCA], [https://pdbe.org/8w7e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8w7e RCSB], [https://www.ebi.ac.uk/pdbsum/8w7e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8w7e ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Ding | == Function == | ||
[[Category: Jiang | [https://www.uniprot.org/uniprot/CLPP_HUMAN CLPP_HUMAN] Clp cleaves peptides in various proteins in a process that requires ATP hydrolysis. Clp may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates. | ||
[[Category: Lu | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: Xiao | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | |||
[[Category: Chen M-R]] | |||
[[Category: Ding H]] | |||
[[Category: Jiang J-X]] | |||
[[Category: Lu M-L]] | |||
[[Category: Sun H-Y]] | |||
[[Category: Xiao Y-B]] | |||
Latest revision as of 05:39, 4 September 2024
Design, synthesis and biological evaluations of novel small molecular hyper-activators of human caseinolytic peptidase P (hClpP)
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