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New page: left|200px<br /> <applet load="1r79" size="450" color="white" frame="true" align="right" spinBox="true" caption="1r79" /> '''Solution Structure of The C1 Domain of The ...
 
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[[Image:1r79.gif|left|200px]]<br />
<applet load="1r79" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1r79" />
'''Solution Structure of The C1 Domain of The Human Diacylglycerol Kinase Delta'''<br />


==About this Structure==
==Solution Structure of The C1 Domain of The Human Diacylglycerol Kinase Delta==
1R79 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Diacylglycerol_kinase Diacylglycerol kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.107 2.7.1.107] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1R79 OCA].  
<StructureSection load='1r79' size='340' side='right'caption='[[1r79]]' scene=''>
[[Category: Diacylglycerol kinase]]
== Structural highlights ==
<table><tr><td colspan='2'>[[1r79]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R79 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R79 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r79 OCA], [https://pdbe.org/1r79 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r79 RCSB], [https://www.ebi.ac.uk/pdbsum/1r79 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r79 ProSAT], [https://www.topsan.org/Proteins/RSGI/1r79 TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DGKD_HUMAN DGKD_HUMAN] May function as signaling molecule.<ref>PMID:17880279</ref>  Isoform 2 may be involved in cell growth and tumorigenesis. Involved in clathrin-dependent endocytosis.<ref>PMID:17880279</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r7/1r79_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r79 ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Diacylglycerol kinase 3D structures|Diacylglycerol kinase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Inoue, M.]]
[[Category: Inoue M]]
[[Category: Kigawa, T.]]
[[Category: Kigawa T]]
[[Category: Koshiba, S.]]
[[Category: Koshiba S]]
[[Category: Miyamoto, K.]]
[[Category: Miyamoto K]]
[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
[[Category: Tomizawa T]]
[[Category: Tomizawa, T.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: ZN]]
[[Category: c1 domain]]
[[Category: cystein-rich zinc binding domain]]
[[Category: diacylglycerol kinase delta]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomics]]
 
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Retrieved from "https://proteopedia.org/1r79"