1rsf: Difference between revisions

From Proteopedia
Jump to navigationJump to search
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
New page: left|200px<br /> <applet load="1rsf" size="450" color="white" frame="true" align="right" spinBox="true" caption="1rsf" /> '''NMR Structure of Monomeric CAR d1 domain'''...
 
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
 
(15 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:1rsf.gif|left|200px]]<br />
<applet load="1rsf" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1rsf" />
'''NMR Structure of Monomeric CAR d1 domain'''<br />


==Overview==
==NMR Structure of Monomeric CAR d1 domain==
The coxsackievirus and adenovirus receptor (CAR) mediates entry of, coxsackievirus B (CVB) and adenovirus (Ad). The normal cellular function, of CAR, which is expressed in a wide variety of tissue types, is thought, to involve homophilic cell adhesion in the developing brain. The, extracellular domain of CAR consists of two immunoglobulin (Ig) domains, termed CAR-D1 and CAR-D2. CAR-D1 is shown by sedimentation velocity to be, monomeric at pH 3.0. The solution structure and the dynamic properties of, monomeric CAR-D1 have been determined by NMR spectroscopy at pH 3.0. The, determinants of the CAR-D1 monomer-dimer equilibrium, as well as the, binding site of CVB and Ad on CAR, are discussed in light of the monomer, structure.
<StructureSection load='1rsf' size='340' side='right'caption='[[1rsf]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1rsf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RSF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RSF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 30 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rsf OCA], [https://pdbe.org/1rsf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rsf RCSB], [https://www.ebi.ac.uk/pdbsum/1rsf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rsf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CXAR_HUMAN CXAR_HUMAN] Component of the epithelial apical junction complex that is essential for the tight junction integrity. Proposed to function as a homophilic cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1/JAML located in the plasma membrane of PMN.<ref>PMID:9096397</ref> <ref>PMID:11734628</ref> <ref>PMID:12297051</ref> <ref>PMID:15800062</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rs/1rsf_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rsf ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The coxsackievirus and adenovirus receptor (CAR) mediates entry of coxsackievirus B (CVB) and adenovirus (Ad). The normal cellular function of CAR, which is expressed in a wide variety of tissue types, is thought to involve homophilic cell adhesion in the developing brain. The extracellular domain of CAR consists of two immunoglobulin (Ig) domains termed CAR-D1 and CAR-D2. CAR-D1 is shown by sedimentation velocity to be monomeric at pH 3.0. The solution structure and the dynamic properties of monomeric CAR-D1 have been determined by NMR spectroscopy at pH 3.0. The determinants of the CAR-D1 monomer-dimer equilibrium, as well as the binding site of CVB and Ad on CAR, are discussed in light of the monomer structure.


==Disease==
Solution structure of the coxsackievirus and adenovirus receptor domain 1.,Jiang S, Jacobs A, Laue TM, Caffrey M Biochemistry. 2004 Feb 24;43(7):1847-53. PMID:14967025<ref>PMID:14967025</ref>
Known diseases associated with this structure: Adrenocortical tumor, somatic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188830 188830]], Carney complex, type 1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188830 188830]], Myxoma, intracardiac OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188830 188830]], Pigmented adrenocortical disease, primary, 1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188830 188830]], Spastic paraplegia-7 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602783 602783]], Thyroid carcinoma, papillary OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188830 188830]]


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
1RSF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1RSF OCA].
</div>
 
<div class="pdbe-citations 1rsf" style="background-color:#fffaf0;"></div>
==Reference==
== References ==
Solution structure of the coxsackievirus and adenovirus receptor domain 1., Jiang S, Jacobs A, Laue TM, Caffrey M, Biochemistry. 2004 Feb 24;43(7):1847-53. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14967025 14967025]
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Caffrey, M.]]
[[Category: Caffrey M]]
[[Category: Jacobs, A.]]
[[Category: Jacobs A]]
[[Category: Jiang, S.]]
[[Category: Jiang S]]
[[Category: Laue, T.M.]]
[[Category: Laue TM]]
[[Category: adenovirus]]
[[Category: car]]
[[Category: coxsackievirus]]
[[Category: nmr]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 19:06:51 2007''
Retrieved from "https://proteopedia.org/1rsf"