8rwz: Difference between revisions
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==Open non-crosslinked structure Brd4BD2-MZ1-(NEDD8)-CRL2VHL== | |||
<StructureSection load='8rwz' size='340' side='right'caption='[[8rwz]], [[Resolution|resolution]] 4.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8rwz]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8RWZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8RWZ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=759:(2~{S},4~{R})-1-[(2~{S})-2-[2-[2-[2-[2-[2-[(9~{S})-7-(4-CHLOROPHENYL)-4,5,13-TRIMETHYL-3-THIA-1,8,11,12-TETRAZATRICYCLO[8.3.0.0^{2,6}]TRIDECA-2(6),4,7,10,12-PENTAEN-9-YL]ETHANOYLAMINO]ETHOXY]ETHOXY]ETHOXY]ETHANOYLAMINO]-3,3-DIMETHYL-BUTANOYL]-~{N}-[[4-(4-METHYL-2,3-DIHYDRO-1,3-THIAZOL-5-YL)PHENYL]METHYL]-4-OXIDANYL-PYRROLIDINE-2-CARBOXAMIDE'>759</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8rwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8rwz OCA], [https://pdbe.org/8rwz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8rwz RCSB], [https://www.ebi.ac.uk/pdbsum/8rwz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8rwz ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Ciulli A]] | |||
[[Category: Crowe C]] | |||
[[Category: Nakasone MA]] | |||
Latest revision as of 04:09, 5 October 2024
Open non-crosslinked structure Brd4BD2-MZ1-(NEDD8)-CRL2VHL
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