8xvu: Difference between revisions
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==Structure of CXCR2 bound to CXCL2 (Ligand-receptor focused map)== | |||
<StructureSection load='8xvu' size='340' side='right'caption='[[8xvu]], [[Resolution|resolution]] 3.09Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8xvu]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8XVU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8XVU FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.09Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8xvu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8xvu OCA], [https://pdbe.org/8xvu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8xvu RCSB], [https://www.ebi.ac.uk/pdbsum/8xvu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8xvu ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Disease == | ||
[[Category: | [https://www.uniprot.org/uniprot/CXCR2_HUMAN CXCR2_HUMAN] Autosomal recessive severe congenital neutropenia due to CXCR2 deficiency. | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/CXCR2_HUMAN CXCR2_HUMAN] Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2. | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | |||
[[Category: Banerjee R]] | |||
[[Category: Ganguly M]] | |||
[[Category: Nureki O]] | |||
[[Category: Saha S]] | |||
[[Category: Sano FK]] | |||
[[Category: Sharma S]] | |||
[[Category: Shihoya W]] | |||
[[Category: Shukla AK]] | |||
Latest revision as of 06:14, 15 January 2025
Structure of CXCR2 bound to CXCL2 (Ligand-receptor focused map)
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