8y71: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 8y71 is ~~ON HOLD~~

==positive allosteric modulator(BMS986187)-bound delta-opioid receptor-Gi complex==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[8y71]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Y71 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=8Y71 FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.97Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1D6B:3,3,6,6-tetramethyl-9-[4-[(2-methylphenyl)methoxy]phenyl]-4,5,7,9-tetrahydro-2~{H}-xanthene-1,8-dione'>A1D6B</scene>, <scene name='pdbligand=A1D6F:4-[(~{S})-[(2~{R},5~{S})-2,5-dimethyl-4-prop-2-enyl-piperazin-1-yl]-(3-methoxyphenyl)methyl]-~{N},~{N}-diethyl-benzamide'>A1D6F</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=8y71 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8y71 OCA], [https://pdbe.org/8y71 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8y71 RCSB], [https://www.ebi.ac.uk/pdbsum/8y71 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8y71 ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Bos taurus]]

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Rattus norvegicus]]

[[Category: Synthetic construct]]

[[Category: Luo P]]

[[Category: Wang Y]]

[[Category: Xu HE]]

[[Category: Xu Y]]

[[Category: Zhuang Y]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8y71 is ON HOLD
+==positive allosteric modulator(BMS986187)-bound delta-opioid receptor-Gi complex==
+<StructureSection load='8y71' size='340' side='right'caption='[[8y71]], [[Resolution|resolution]] 2.97&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8y71]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Y71 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Y71 FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.97&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1D6B:3,3,6,6-tetramethyl-9-[4-[(2-methylphenyl)methoxy]phenyl]-4,5,7,9-tetrahydro-2~{H}-xanthene-1,8-dione'>A1D6B</scene>, <scene name='pdbligand=A1D6F:4-[(~{S})-[(2~{R},5~{S})-2,5-dimethyl-4-prop-2-enyl-piperazin-1-yl]-(3-methoxyphenyl)methyl]-~{N},~{N}-diethyl-benzamide'>A1D6F</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8y71 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8y71 OCA], [https://pdbe.org/8y71 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8y71 RCSB], [https://www.ebi.ac.uk/pdbsum/8y71 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8y71 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Bos taurus]]
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Rattus norvegicus]]
+[[Category: Synthetic construct]]
+[[Category: Luo P]]
+[[Category: Wang Y]]
+[[Category: Xu HE]]
+[[Category: Xu Y]]
+[[Category: Zhuang Y]]