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New page: left|200px<br /> <applet load="1sbx" size="450" color="white" frame="true" align="right" spinBox="true" caption="1sbx, resolution 1.65Å" /> '''Crystal structure o...
 
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[[Image:1sbx.gif|left|200px]]<br />
<applet load="1sbx" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1sbx, resolution 1.65&Aring;" />
'''Crystal structure of the Dachshund-homology domain of human SKI'''<br />


==Overview==
==Crystal structure of the Dachshund-homology domain of human SKI==
The nuclear protooncoprotein SKI negatively regulates transforming growth, factor-beta (TGF-beta) signaling in cell growth and differentiation. It, directly interacts with the Smads and, by various mechanisms, represses, the transcription of TGF-beta-responsive genes. SKI is a multidomain, protein that includes a domain bearing high sequence similarity with the, retinal determination protein Dachshund (the Dachshund homology domain, DHD). The SKI-DHD has been implicated in SMAD-2/3, N-CoR, SKIP, and, PML-RARalpha binding. The 1.65 A crystal structure of the Dachshund, homology domain of human SKI is reported here. The SKI-DHD adopts a mixed, alpha/beta structure which includes features found in the, forkhead/winged-helix family of DNA binding proteins, although SKI-DHD is, not a DNA binding domain. Residues that form a contiguous surface patch on, SKI-DHD are conserved within the Ski/Sno family and with Dachshund, suggesting that this domain may mediate intermolecular interactions common, to these proteins.
<StructureSection load='1sbx' size='340' side='right'caption='[[1sbx]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1sbx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SBX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sbx OCA], [https://pdbe.org/1sbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sbx RCSB], [https://www.ebi.ac.uk/pdbsum/1sbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sbx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SKI_HUMAN SKI_HUMAN] May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling.<ref>PMID:19049980</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sb/1sbx_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sbx ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The nuclear protooncoprotein SKI negatively regulates transforming growth factor-beta (TGF-beta) signaling in cell growth and differentiation. It directly interacts with the Smads and, by various mechanisms, represses the transcription of TGF-beta-responsive genes. SKI is a multidomain protein that includes a domain bearing high sequence similarity with the retinal determination protein Dachshund (the Dachshund homology domain, DHD). The SKI-DHD has been implicated in SMAD-2/3, N-CoR, SKIP, and PML-RARalpha binding. The 1.65 A crystal structure of the Dachshund homology domain of human SKI is reported here. The SKI-DHD adopts a mixed alpha/beta structure which includes features found in the forkhead/winged-helix family of DNA binding proteins, although SKI-DHD is not a DNA binding domain. Residues that form a contiguous surface patch on SKI-DHD are conserved within the Ski/Sno family and with Dachshund, suggesting that this domain may mediate intermolecular interactions common to these proteins.


==Disease==
Crystal structure of the dachshund homology domain of human SKI.,Wilson JJ, Malakhova M, Zhang R, Joachimiak A, Hegde RS Structure. 2004 May;12(5):785-92. PMID:15130471<ref>PMID:15130471</ref>
Known disease associated with this structure: 1p36 deletion syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164780 164780]]


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
1SBX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1SBX OCA].
</div>
 
<div class="pdbe-citations 1sbx" style="background-color:#fffaf0;"></div>
==Reference==
== References ==
Crystal structure of the dachshund homology domain of human SKI., Wilson JJ, Malakhova M, Zhang R, Joachimiak A, Hegde RS, Structure. 2004 May;12(5):785-92. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15130471 15130471]
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Hegde, R.S.]]
[[Category: Hegde RS]]
[[Category: Joachimiak, A.]]
[[Category: Joachimiak A]]
[[Category: Malakhova, M.]]
[[Category: Malakhova M]]
[[Category: Wilson, J.J.]]
[[Category: Wilson JJ]]
[[Category: Zhang, R.]]
[[Category: Zhang R]]
[[Category: forkhead]]
[[Category: winged helix]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 19:12:17 2007''
Retrieved from "https://proteopedia.org/1sbx"