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[[Image:1qc1.gif|left|200px]]


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==CRYSTAL STRUCTURE OF THE SELF-FITTED B-DNA DECAMER D(CCGCCGGCGG)==
The line below this paragraph, containing "STRUCTURE_1qc1", creates the "Structure Box" on the page.
<StructureSection load='1qc1' size='340' side='right'caption='[[1qc1]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1qc1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QC1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QC1 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
{{STRUCTURE_1qc1|  PDB=1qc1  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qc1 OCA], [https://pdbe.org/1qc1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qc1 RCSB], [https://www.ebi.ac.uk/pdbsum/1qc1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qc1 ProSAT]</span></td></tr>
 
</table>
'''CRYSTAL STRUCTURE OF THE SELF-FITTED B-DNA DECAMER D(CCGCCGGCGG)'''
__TOC__
 
</StructureSection>
 
[[Category: Large Structures]]
==Overview==
[[Category: Moras D]]
Groove-backbone interaction is a natural and biologically relevant mechanism for the specific assembly of B-DNA double helices. Crystal engineering and crystal packing analysis of oligonucleotides of different sizes and sequences reveal that the sequence-dependent self-fitting of B-DNA helices is a dominant constraint for their ordered assembly. It can override the other intermolecular interactions and impose the overall geometry of the packing. Analysis of experimental examples of architectural motifs formed by the geometric combination of self-fitted DNA segments leads to general rules for DNA assembly. Like a directing piece for a supramolecular 'construction set', the double helix imposes a limited number of geometric solutions. These basic architectural constraints could direct, in a codified manner, the formation of higher-order structures. DNA architectural motifs exhibit new structural and electrostatic properties which could have some implications for their molecular recognition by proteins acting on DNA.
[[Category: Timsit Y]]
 
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QC1 OCA].  
 
==Reference==
DNA self-fitting: the double helix directs the geometry of its supramolecular assembly., Timsit Y, Moras D, EMBO J. 1994 Jun 15;13(12):2737-46. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8026458 8026458]
[[Category: Moras, D.]]
[[Category: Timsit, Y.]]
[[Category: B-dna double-helix]]
[[Category: Dna-dna recognition]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 06:06:59 2008''

Latest revision as of 08:14, 14 February 2024

CRYSTAL STRUCTURE OF THE SELF-FITTED B-DNA DECAMER D(CCGCCGGCGG)

1qc1, resolution 2.50Å

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