Ubiquitin-fold modifier: Difference between revisions
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== Function == | == Function == | ||
'''Ubiquitin-fold modifier''' (Ufm1) is a member of the ubiquitin-like family. Ufm1 is covalently attached to Lys residues of substrate proteins<ref>PMID:21494687</ref>. This attachment is called Ufmylation and requires '''Ubiquitin-like modifier activating enzyme''' ( | '''Ubiquitin-fold modifier''' (Ufm1) is a member of the ubiquitin-like family. Ufm1 is covalently attached to Lys residues of substrate proteins<ref>PMID:21494687</ref>. This attachment is called Ufmylation and requires '''Ubiquitin-like modifier activating enzyme''' (Uba5) and '''Ufm1-conjugating enzyme''' (Ufc1). Ufmylation is a type of post-translational modification that deals with fine-tuned and complex cellular activities and is involved in reticulophagy induced by ER stress<ref>PMID:31129212</ref>. Ufmylation is aribosomal modification specialized to facilitate metazoan-specific protein biogenesis at the ER<ref>PMID:30626644</ref>. | ||
== Relevance == | == Relevance == | ||
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[[Ubiquitin-fold modifier 3D structures]] | [[Ubiquitin-fold modifier 3D structures]] | ||
==References== | ==References== | ||
<references /> | <references /> | ||
</StructureSection> | </StructureSection> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
