8xsm: Difference between revisions

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'''Unreleased structure'''


The entry 8xsm is ON HOLD  until Paper Publication
==transporter==
 
<StructureSection load='8xsm' size='340' side='right'caption='[[8xsm]], [[Resolution|resolution]] 3.01&Aring;' scene=''>
Authors: Jiang, D.H., Wang, K.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8xsm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8XSM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8XSM FirstGlance]. <br>
Description: transporter
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.01&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RBF:RIBOFLAVIN'>RBF</scene></td></tr>
[[Category: Wang, K]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8xsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8xsm OCA], [https://pdbe.org/8xsm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8xsm RCSB], [https://www.ebi.ac.uk/pdbsum/8xsm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8xsm ProSAT]</span></td></tr>
[[Category: Jiang, D.H]]
</table>
== Disease ==
[https://www.uniprot.org/uniprot/S52A2_HUMAN S52A2_HUMAN] RFVT2-related riboflavin transporter deficiency. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/S52A2_HUMAN S52A2_HUMAN] Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism (PubMed:20463145, PubMed:22864630, PubMed:23243084, PubMed:24253200, PubMed:27702554). Humans are unable to synthesize vitamin B2/riboflavin and must obtain it via intestinal absorption (PubMed:20463145). May also act as a receptor for 4-hydroxybutyrate (Probable).<ref>PMID:20463145</ref> <ref>PMID:22864630</ref> <ref>PMID:23243084</ref> <ref>PMID:24253200</ref> <ref>PMID:27702554</ref> <ref>PMID:20463145</ref> <ref>PMID:17197387</ref>  (Microbial infection) In case of infection by retroviruses, acts as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A).<ref>PMID:12740431</ref> <ref>PMID:19307586</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Jiang DH]]
[[Category: Wang K]]
Retrieved from "https://proteopedia.org/8xsm"