8yk4: Difference between revisions
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New page: '''Unreleased structure''' The entry 8yk4 is ON HOLD Authors: Description: Category: Unreleased Structures |
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==Structure of SARS-CoV-2 RBD and antibody NT-108== | |||
<StructureSection load='8yk4' size='340' side='right'caption='[[8yk4]], [[Resolution|resolution]] 3.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8yk4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8YK4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8YK4 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8yk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8yk4 OCA], [https://pdbe.org/8yk4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8yk4 RCSB], [https://www.ebi.ac.uk/pdbsum/8yk4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8yk4 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/A0A7U3DZD0_SARS2 A0A7U3DZD0_SARS2] Spike protein S1: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection.[HAMAP-Rule:MF_04099] Spike protein S2': Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099] Spike protein S2: mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Severe acute respiratory syndrome coronavirus 2]] | |||
[[Category: Adachi Y]] | |||
[[Category: Anraku Y]] | |||
[[Category: Fukuhara H]] | |||
[[Category: Hashiguchi T]] | |||
[[Category: Ito S]] | |||
[[Category: Iwata N]] | |||
[[Category: Kazuki Y]] | |||
[[Category: Kita S]] | |||
[[Category: Maenaka K]] | |||
[[Category: Nagata N]] | |||
[[Category: Onodera T]] | |||
[[Category: Orba Y]] | |||
[[Category: Oshimura M]] | |||
[[Category: Sasaki J]] | |||
[[Category: Sasaki M]] | |||
[[Category: Sato A]] | |||
[[Category: Sawa H]] | |||
[[Category: Shiwa N]] | |||
[[Category: Suzuki T]] | |||
[[Category: Tadokoro T]] | |||
[[Category: Takahashi Y]] | |||
Latest revision as of 10:23, 12 March 2025
Structure of SARS-CoV-2 RBD and antibody NT-108
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