9ax5: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 9ax5 is ~~ON HOLD~~

==Cryo-EM structure of Phospholipase C epsilon PH-C terminus in complex with RhoA-GTP==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[9ax5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9AX5 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9AX5 FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9ax5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ax5 OCA], [https://pdbe.org/9ax5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ax5 RCSB], [https://www.ebi.ac.uk/pdbsum/9ax5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ax5 ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/PLCE1_RAT PLCE1_RAT] The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. In podocytes, is involved in the regulation of lamellipodia formation. Acts downtream of AVIL to allow ARP2/3 complex assembly (By similarity).[UniProtKB:Q9P212]<ref>PMID:12721365</ref> <ref>PMID:16314422</ref> <ref>PMID:17086182</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Rattus norvegicus]]

[[Category: Lyon AM]]

[[Category: Ohri V]]

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-'''Unreleased structure'''
-The entry 9ax5 is ON HOLD
+==Cryo-EM structure of Phospholipase C epsilon PH-C terminus in complex with RhoA-GTP==
+<StructureSection load='9ax5' size='340' side='right'caption='[[9ax5]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9ax5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9AX5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9AX5 FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ax5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ax5 OCA], [https://pdbe.org/9ax5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ax5 RCSB], [https://www.ebi.ac.uk/pdbsum/9ax5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ax5 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PLCE1_RAT PLCE1_RAT] The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. In podocytes, is involved in the regulation of lamellipodia formation. Acts downtream of AVIL to allow ARP2/3 complex assembly (By similarity).[UniProtKB:Q9P212]<ref>PMID:12721365</ref> <ref>PMID:16314422</ref> <ref>PMID:17086182</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Rattus norvegicus]]
+[[Category: Lyon AM]]
+[[Category: Ohri V]]