1t5q: Difference between revisions

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New page: left|200px<br /> <applet load="1t5q" size="450" color="white" frame="true" align="right" spinBox="true" caption="1t5q" /> '''Solution Structure of GIP(1-30)amide in TFE...
 
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[[Image:1t5q.gif|left|200px]]<br />
<applet load="1t5q" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1t5q" />
'''Solution Structure of GIP(1-30)amide in TFE/Water'''<br />


==Overview==
==Solution Structure of GIP(1-30)amide in TFE/Water==
Glucose-dependent insulinotropic polypeptide is an incretin hormone that, stimulates insulin secretion and reduces postprandial glycaemic, excursions. The glucose-dependent action of GIP on pancreatic beta-cells, has attracted attention towards its exploitation as a potential drug for, type 2 diabetes. Use of NMR or X-ray crystallography is vital to determine, the three-dimensional structure of the peptide. Therefore, to understand, the basic structural requirements for the biological activity of GIP, the, solution structure of the major biologically active fragment, GIP(1-30)amide, was investigated by proton NMR spectroscopy and molecular, modelling. The structure is characterised by a full length alpha-helical, conformation between residues F(6) and A(28). This structural information, could play an important role in the design of therapeutic agents based, upon GIP receptor agonists.
<StructureSection load='1t5q' size='340' side='right'caption='[[1t5q]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1t5q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T5Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T5Q FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t5q OCA], [https://pdbe.org/1t5q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t5q RCSB], [https://www.ebi.ac.uk/pdbsum/1t5q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t5q ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GIP_HUMAN GIP_HUMAN] Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Glucose-dependent insulinotropic polypeptide is an incretin hormone that stimulates insulin secretion and reduces postprandial glycaemic excursions. The glucose-dependent action of GIP on pancreatic beta-cells has attracted attention towards its exploitation as a potential drug for type 2 diabetes. Use of NMR or X-ray crystallography is vital to determine the three-dimensional structure of the peptide. Therefore, to understand the basic structural requirements for the biological activity of GIP, the solution structure of the major biologically active fragment, GIP(1-30)amide, was investigated by proton NMR spectroscopy and molecular modelling. The structure is characterised by a full length alpha-helical conformation between residues F(6) and A(28). This structural information could play an important role in the design of therapeutic agents based upon GIP receptor agonists.


==Disease==
NMR structure of the glucose-dependent insulinotropic polypeptide fragment, GIP(1-30)amide.,Alana I, Hewage CM, Malthouse JP, Parker JC, Gault VA, O'Harte FP Biochem Biophys Res Commun. 2004 Dec 3;325(1):281-6. PMID:15522230<ref>PMID:15522230</ref>
Known diseases associated with this structure: Pituitary ACTH-secreting adenoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=139360 139360]], Ventricular tachycardia, idiopathic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=139360 139360]]


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
1T5Q is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1T5Q OCA].
</div>
 
<div class="pdbe-citations 1t5q" style="background-color:#fffaf0;"></div>
==Reference==
== References ==
NMR structure of the glucose-dependent insulinotropic polypeptide fragment, GIP(1-30)amide., Alana I, Hewage CM, Malthouse JP, Parker JC, Gault VA, O'Harte FP, Biochem Biophys Res Commun. 2004 Dec 3;325(1):281-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15522230 15522230]
<references/>
[[Category: Single protein]]
__TOC__
[[Category: Alana, I.]]
</StructureSection>
[[Category: Gault, V.A.]]
[[Category: Homo sapiens]]
[[Category: Harte, F.P.M.O.]]
[[Category: Large Structures]]
[[Category: Hewage, C.M.]]
[[Category: Alana I]]
[[Category: Malthouse, J.P.G.]]
[[Category: Gault VA]]
[[Category: Parker, J.C.]]
[[Category: Hewage CM]]
[[Category: diabetes]]
[[Category: Malthouse JPG]]
[[Category: gip]]
[[Category: O'Harte FPM]]
[[Category: helix]]
[[Category: Parker JC]]
[[Category: molecular modelling]]
[[Category: nmr]]
[[Category: obesity]]
 
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