9epo: Difference between revisions
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New page: '''Unreleased structure''' The entry 9epo is ON HOLD Authors: Description: Category: Unreleased Structures |
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==High resolution structure of FZD7 in inactive conformation== | |||
<StructureSection load='9epo' size='340' side='right'caption='[[9epo]], [[Resolution|resolution]] 1.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9epo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9EPO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9EPO FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 1.9Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9epo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9epo OCA], [https://pdbe.org/9epo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9epo RCSB], [https://www.ebi.ac.uk/pdbsum/9epo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9epo ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/FZD7_HUMAN FZD7_HUMAN] Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Adebali O]] | |||
[[Category: Bous J]] | |||
[[Category: Gratz L]] | |||
[[Category: Kinsolving J]] | |||
[[Category: Scharf MM]] | |||
[[Category: Schulte G]] | |||
[[Category: Selcuk B]] | |||
[[Category: Voss J]] | |||
Latest revision as of 04:04, 5 October 2024
High resolution structure of FZD7 in inactive conformation
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