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| [[Image:1rid.gif|left|200px]]
| | <span style='background-color: yellow;'>For additional information see '''2009, December:''' at [[Retractions and Fraud]].</span></br>REMOVED: The PDB entry 1rid was removed. |
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| {{STRUCTURE_1rid| PDB=1rid | SCENE= }}
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| '''Vaccinia Complement Protein in Complex with Heparin''' | |
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| ==Overview==
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| Vaccinia virus complement control protein (VCP), a homolog of the regulators of the complement activation family of proteins, inhibits complement activation through mechanisms similar to human fluid-phase complement regulators factor H and C4b-binding protein. VCP has a heparin-binding activity that assists vaccinia in host interactions. Interaction with cell-surface polyanions like heparin is centrally important in the functioning of fluid-phase complement regulators and is the basis of host-target discrimination by the alternative pathway. We report the structure of VCP in complex with a heparin decasaccharide, which reveals changes in VCP that might be pertinent to complement regulation. Properties that VCP shares with fluid-phase complement regulators suggest that such conformational changes may be of relevance in the functioning of other complement regulators. Additionally, comparison of VCP-heparin interactions with potentially similar interactions in factor H might enable understanding of the structural basis of familial hemolytic uremic syndrome, attributed to mutational disruption of heparin and C3b binding by factor H.
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| ==About this Structure==
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| 1RID is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RID OCA].
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| ==Reference==
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| Structure of vaccinia complement protein in complex with heparin and potential implications for complement regulation., Ganesh VK, Smith SA, Kotwal GJ, Murthy KH, Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8924-9. Epub 2004 Jun 3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15178763 15178763]
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| [[Category: Single protein]]
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| [[Category: Vaccinia virus]]
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| [[Category: Ganesh, V K.]]
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| [[Category: Kotwal, G J.]]
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| [[Category: Murthy, K H.M.]]
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| [[Category: Smith, S A.]]
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| [[Category: Complement]]
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| [[Category: Regulation]]
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| [[Category: Scr]]
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| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:31:56 2008''
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