Coatomer: Difference between revisions

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'''Coatomers''' (COPI) are a set of vesicles' coating proteins <ref>PMID:~~898986~~</ref>. Coatomers contain several subunits which are named according to decreasing molecular weight as alpha, beta', gamma, delta, epsilon and zeta-1. Protein ADP-ribosylation factor 1 (Arf-1) is part of the vesicle-coating complex<ref>PMID:9681627</ref>.

'''Coatomers''' (COPI) are a set of vesicles' coating proteins <ref>PMID:1898986</ref>. Coatomers contain several subunits which are named according to decreasing molecular weight as alpha, beta', gamma, delta, epsilon and zeta-1. Protein ADP-ribosylation factor 1 (Arf-1) is part of the vesicle-coating complex<ref>PMID:9681627</ref>.

== Function ==

COPI function in the sorting and trafficking of proteins between sub cellular organelles <ref>PMID:34450031</ref>. COP1 induces membrane curvature during budding<ref>PMID:21893600</ref>. Dilysine motifs on transmembrane proteins are recognised by COPI alpha and beta' subunits and packaged into COPI-coated vesicles for transport from Golgi to ER<ref>PMID:23481256</ref>.

== Disease ==

Mutations in COPI can result in osteoporosis, fractures and developmental delays. Deficiency in COPI alpha subunit cause COPA syndrome<ref>PMID:~~3584149~~</ref>.

Mutations in COPI can result in osteoporosis, fractures and developmental delays. Deficiency in COPI alpha subunit cause COPA syndrome<ref>PMID:30804679</ref>.

== Structural highlights ==

The COPI/Arf-1 complex consists of subunit alpha, subunit beta, subunit beta', subunit gamma-1, subunit delta, subunit zeta-1 and protein Arf-1<ref>PMID:28621666</ref>.

The <scene name='10/1041515/Cv/3'>COPI/Arf-1 complex</scene> consists of subunit alpha, subunit beta, subunit beta', subunit gamma-1, subunit delta, subunit zeta-1 and protein Arf-1<ref>PMID:28621666</ref>.

==Coatomer 3D structures==

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-<StructureSection load='5nzu' size='350' side='right' caption='Mouse COPI coat complex containing subunits alpha (grey), beta (green), beta prime (pink), delta (yellow), gamma-1 (red), zeta-1 (aqua) and protein Arf-1 (cyan) (PDB entry [[5nzu]])' scene=>
+<StructureSection load='5nzu' size='350' side='right' caption='Mouse COPI coat complex containing subunits alpha (grey), beta (green), beta prime (pink), delta (yellow), gamma-1 (red), zeta-1 (aqua) and protein Arf-1 (cyan) (PDB entry [[5nzu]])' scene='10/1041515/Cv/2'>
-'''Coatomers''' (COPI) are a set of vesicles' coating proteins <ref>PMID:898986</ref>.  Coatomers contain several subunits which are named according to decreasing molecular weight as alpha, beta', gamma, delta, epsilon and zeta-1.  Protein ADP-ribosylation factor 1 (Arf-1) is part of the vesicle-coating complex<ref>PMID:9681627</ref>.
+'''Coatomers''' (COPI) are a set of vesicles' coating proteins <ref>PMID:1898986</ref>.  Coatomers contain several subunits which are named according to decreasing molecular weight as alpha, beta', gamma, delta, epsilon and zeta-1.  Protein ADP-ribosylation factor 1 (Arf-1) is part of the vesicle-coating complex<ref>PMID:9681627</ref>.
 == Function ==
-COPI function in the sorting and trafficking of proteins between sub cellular organelles <ref>PMID:34450031</ref>.  COP1 induces membrane curvature during budding<ref>PMID:21893600</ref>. Dilysine motifs on transmembrane proteins are recognised by COPI alpha and beta' subunits and packaged into COPI-coated vesicles for transport from Golgi to ER<ref>PMID:23481256</ref>.
+COPI function in the sorting and trafficking of proteins between sub cellular organelles <ref>PMID:34450031</ref>. COP1 induces membrane curvature during budding<ref>PMID:21893600</ref>. Dilysine motifs on transmembrane proteins are recognised by COPI alpha and beta' subunits and packaged into COPI-coated vesicles for transport from Golgi to ER<ref>PMID:23481256</ref>.
 == Disease ==
-Mutations in COPI can result in osteoporosis, fractures and developmental delays.  Deficiency in COPI alpha subunit cause COPA syndrome<ref>PMID:3584149</ref>.
+Mutations in COPI can result in osteoporosis, fractures and developmental delays.  Deficiency in COPI alpha subunit cause COPA syndrome<ref>PMID:30804679</ref>.
 == Structural highlights ==
-The COPI/Arf-1 complex consists of subunit alpha, subunit beta, subunit beta', subunit gamma-1, subunit delta, subunit zeta-1 and protein Arf-1<ref>PMID:28621666</ref>.
+The <scene name='10/1041515/Cv/3'>COPI/Arf-1 complex</scene> consists of subunit alpha, subunit beta, subunit beta', subunit gamma-1, subunit delta, subunit zeta-1 and protein Arf-1<ref>PMID:28621666</ref>.
 ==Coatomer 3D structures==